Tall BP lowering having supplemental amounts away from potassium on assortment out of 1900 to 4700 milligrams/d (49–122 mmol/d) has been said to bring about BP decrease in up to 2 to six mm hg to have diastolic BP and 2 to 4 mm hg to own systolic BP. this new highest variability ranging from results reflects this new variability seen in additional knowledge. while doing so, the end result from potassium on the BP is dependent on pretreatment BP level; age; race; sex; comorbid criteria; intake from salt, magnesium, calcium, or any other ions; diet; exercise; weight; kind of potassium utilized; concomitant medication; and you may lifetime of explore. a listing of the newest findings of all of the meta-analyses on the aftereffects of potassium to the BP thus https://datingranking.net/tr/asiandate-inceleme/ far is given from inside the Profile step 3.
Review of meta-analyses out of education investigating the blood pressure-reducing effects of potassium. 25–28 SBP indicates systolic blood pressure levels; DBP, diastolic blood pressure level.
Though conflicting performance regarding your negative effects of potassium supplementation toward BP had been claimed in the scientific studies, 34, 35 new samples features displayed show in keeping with that of the newest meta-studies by the Whelton and you will colleagues twenty six (Table II). Gu and colleagues 36 learned that average potassium supplementation (sixty mmol KCl) drawn to own 12 days lead to a decrease in systolic BP, not diastolic BP, in the a Chinese people. Furthermore, Kawano and you can colleagues 37 documented one an effective cuatro-week potassium supplements months (during which 64 mmol/d out-of potassium obtained as the sluggish-discharge KCl) triggered brief however, high decrease in work environment, domestic, and you will 24-time BP within the Japanese group. Braschi and you will associates 38 subsequent examined the effect away from lower-dosage potassium supplements to the BP and discovered that 24 mmol/d out-of sluggish-release KCl applied getting 6 weeks led to high decrease in the suggest arterial pressure and you will diastolic BP inside the match volunteers.
Elements where Potassium Reduces BP
Brand new homeostasis out-of salt and you can potassium plays a crucial role when you look at the endothelium-situated vasodilatation. 39 Sodium storage decreases the synthesis from nitric oxide, a keen arteriolar vasodilator elaborated by the endothelial structure, and increases the plasma number of asymmetric dimethyl-L-arginine, an enthusiastic endogenous substance away from nitric oxide creation. forty a nutrition full of potassium and expands from inside the gel potassium, also into the physiologic assortment, result in endothelium-created vasodilatation from the hyperpolarizing this new endothelial mobile as a result of stimulation of your sodium push and you will beginning potassium channels. 41 At exactly the same time, most other suggested components in which potassium is also dictate BP is natriuresis, modulation of baroreceptor susceptibility, smaller vasoconstrictive sensitivity to help you norepinephrine and angiotensin II, increased gel and you may urinary kallikrein, increased salt/potassium Within Pase pastime, customization inside the DNA synthesis, and you will proliferation inside vascular simple muscle tissue and you may sympathetic neurological system muscle. 42, 43
Losing weight Recommendations to have Potassium
Maintaining an adequate intake of dietary potassium (>90 mmol [3500 mg]/d) has been recommended for the primary prevention of hypertension by the JNC 7.13 The Institute of Medicine has recommended a sodium intake <65 mmol/d (3.8 g/d) and an increase in potassium to 120 mmol/d. 44 In 2006, the American Heart Association issued new guidelines suggesting an increase in potassium intake to 120 mmol/d (4.7 g/d), which is the level provided in the DASH diets in which all food is supplied. 14 The Canadian Hypertension Society recommends that the daily dietary intake of potassium should be ?60 mmol, since this intake has been associated with a reduced risk of stroke-related mortality. 45, 46 The most recent European Society of Hypertension guidelines also support an increased potassium intake based on the DASH diet. 18 In addition, the 2003 World Health Organization/International Society of Hypertension statement recommends a diet high in fruits and vegetables, a reduction of dietary sodium intake, and increased dietary potassium intake for reducing the incidence of hypertension. 16 Some sources of high-potassium, low-sodium foods are listed in Table III. 47